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Boc-Tyr(OtBu)-Gln(Trt)-Gly-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the tyrosine (Tyr) residue, preventing it from reacting during synthesis. The hydroxyl group of tyrosine and the side chain amide group of glutamine (Gln) are protected by OtBu (tert-butyl) and Trt (Trityl) groups, respectively, which shield these functional groups from unwanted reactions until deprotection is carried out. Gly (Glycine), the final amino acid in the sequence, has a free carboxyl group at the C-terminus, indicated by -OH, allowing for further peptide coupling or modifications. This peptide is used to introduce tyrosine, glutamine, and glycine into peptides, with specific protection strategies ensuring controlled and efficient peptide synthesis.
