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Cbz-Thr(OtBu)-Phe-Thr(OtBu)-OMe is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the threonine (Thr) residue, preventing it from participating in unwanted reactions. The hydroxyl groups on both threonine residues are protected by OtBu (tert-butyl) groups, ensuring these functional groups remain unreactive until selective deprotection is required. Phe (Phenylalanine), positioned in the middle, adds aromatic and hydrophobic properties to the peptide. The OMe (methyl ester) at the C-terminus indicates that the carboxyl group of the final threonine is esterified, which can facilitate further reactions or modifications. This compound is used to incorporate threonine and phenylalanine into peptides, with controlled reactivity through selective protection, enabling precise and efficient peptide synthesis.
