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H-Glu(OtBu)-Ile-Pro-OMe is a protected tripeptide used in peptide synthesis. The H indicates a free N-terminus on the glutamic acid (Glu) residue, which is protected on its side chain by an OtBu (tert-butyl) group, preventing the carboxyl group from reacting during synthesis. Ile (Isoleucine) is the middle amino acid, contributing hydrophobic properties, while Pro (Proline), the last amino acid, is known for its ability to induce turns or kinks in peptide chains due to its rigid structure. The OMe (methyl ester) at the C-terminus means the carboxyl group of proline is esterified, which can be advantageous for further chemical modifications or to prevent unwanted reactions during peptide elongation. This tripeptide is used to introduce glutamic acid, isoleucine, and proline into peptides, with selective protection to ensure controlled reactivity throughout the synthesis process.
