N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-pyridyl)-L-β-homoalanine
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N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-pyridyl)-L-β-homoalanine

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Category
Fmoc-Amino Acids
Catalog number
BAT-004698
CAS number
270063-60-0
Molecular Formula
C24H22N2O4
Molecular Weight
402.45
N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-pyridyl)-L-β-homoalanine
IUPAC Name
(3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-pyridin-3-ylbutanoic acid
Synonyms
Fmoc-Ala(3-Pyri)-(C#CH2)OH; (S)-3-[(9-Fluorenylmethoxycarbonyl)amino]-4-(3-pyridyl)butanoic acid
Purity
95%
Density
1.285g/cm3
Boiling Point
657.7°C at 760mmHg
Storage
Store at 2-8 °C
InChI
InChI=1S/C24H22N2O4/c27-23(28)13-17(12-16-6-5-11-25-14-16)26-24(29)30-15-22-20-9-3-1-7-18(20)19-8-2-4-10-21(19)22/h1-11,14,17,22H,12-13,15H2,(H,26,29)(H,27,28)/t17-/m0/s1
InChI Key
QBMDHZYUTBFELW-KRWDZBQOSA-N
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CN=CC=C4)CC(=O)O

N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-pyridyl)-L-β-homoalanine, a synthetic amino acid derivative, finds extensive utility in biochemical and pharmaceutical research. Here are the key applications, each presented with a high degree of perplexity and burstiness:

Peptide Synthesis: This compound acts as a pivotal building block in custom peptide synthesis, where the fluorenylmethoxycarbonyl (Fmoc) group plays a crucial role as a protective entity during the intricate assembly of peptide chains. This method allows for the meticulous and streamlined creation of complex peptides with tailored functionalities, elevating the precision and efficiency of peptide synthesis endeavors.

Drug Discovery: Leveraging the unique chemical structure of N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-pyridyl)-L-β-homoalanine, researchers delve into the realm of developing novel peptide-based drugs. Through strategic modifications facilitated by this compound, scientists can augment drug activity and stability. Incorporating it into drug candidates opens up new avenues for therapeutic exploration, propelling drug efficacy enhancements and catalyzing advancements in drug discovery landscapes.

Protein Engineering: Within the domain of protein engineering, this compound serves as a vital tool for targeted incorporation into proteins, enabling detailed investigations into protein structure, dynamics, and interactions. By substituting natural amino acids with this derivative, researchers unlock the realm of specific protein property exploration and the development of proteins harboring novel functionalities, enriching the possibilities within protein engineering endeavors.

Chemical Biology: N-β-(9-Fluorenylmethoxycarbonyl)-γ-(3-pyridyl)-L-β-homoalanine emerges as a potent asset in the sphere of chemical biology, offering a versatile approach to probe biological systems within cells. Whether integrated into peptides or small molecules, this compound facilitates the exploration of molecular mechanisms underpinning biological processes, thereby illuminating potential therapeutic targets and paving the way for refined interventions in chemical biology research.

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