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Boc-His(Trt)-Aib-Gln(Trt)-OH is a protected tripeptide used in peptide synthesis. The Boc (tert-Butoxycarbonyl) group protects the N-terminus of the histidine (His) residue, preventing it from reacting during synthesis. The side chain imidazole group of histidine and the amide group of glutamine (Gln) are protected by Trt (Trityl) groups, shielding these functional groups from unwanted reactions until selective deprotection is performed. Aib (α-aminoisobutyric acid), known for inducing helical structures, is the middle residue. The -OH at the C-terminus of glutamine indicates a free carboxyl group, allowing for further coupling or modifications. This peptide is used to incorporate histidine, Aib, and glutamine into peptides, with specific protections to ensure controlled and efficient peptide synthesis.
