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Cbz-Glu(OtBu)-Ile-Pro-OMe is a protected tripeptide used in peptide synthesis. The Cbz (Carbobenzyloxy) group protects the N-terminus of the glutamic acid (Glu) residue, preventing it from participating in unwanted reactions. The side chain of glutamic acid is further protected by an OtBu (tert-butyl) group, which shields the carboxyl group from reactivity until selective deprotection is required. Ile (Isoleucine), the middle amino acid in the sequence, adds hydrophobic properties, while Pro (Proline) is the third amino acid, known for inducing kinks in peptide chains due to its rigid cyclic structure. The OMe (methyl ester) at the C-terminus indicates that the carboxyl group of proline is esterified, which can be useful in controlling reactivity or further synthetic modifications. This compound is used to incorporate glutamic acid, isoleucine, and proline into peptides while maintaining precise control over the reactivity of the functional groups.
