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Excellent resin for the synthesis of peptide acids using Fmoc strategy. Cleavage can be effected by 95% TFA.
Fmoc-Glu(OtBu)-Wang resin is a commonly used resin in solid-phase peptide synthesis (SPPS), providing a reliable foundation for various applications. Here are some key applications of Fmoc-Glu(OtBu)-Wang resin:
Peptide Synthesis: This resin is pivotal in the synthesis of peptides using the Fmoc/tBu strategy. It allows for the attachment of the growing peptide chain to a solid support, facilitating multiple cycles of coupling and deprotection. The use of Fmoc-Glu(OtBu)-Wang resin ensures the stability and efficiency of the peptide synthesis process, resulting in high-quality peptides for research and therapeutic use.
Combinatorial Chemistry: Fmoc-Glu(OtBu)-Wang resin is advantageous in the generation of peptide libraries for high-throughput screening. Its capacity to support parallel synthesis methods enables researchers to rapidly create diverse peptide libraries. These libraries are invaluable for drug discovery efforts, identifying potential leads from a pool of peptide candidates.
Pharmaceutical Development: In the pharmaceutical industry, this resin is used to produce peptide-based drugs or drug candidates. The ability to precisely control peptide sequences and modifications makes it suitable for developing peptides with enhanced therapeutic properties. Fmoc-Glu(OtBu)-Wang resin plays a crucial role in the advancement of peptide therapeutics, offering solutions for various medical conditions.
Structural Biology: Researchers employ Fmoc-Glu(OtBu)-Wang resin in the production of labeled peptides or peptide fragments for structural studies. These peptides can be labeled with isotopes or fluorescent tags to investigate protein-peptide interactions and structural dynamics. Such studies are key in understanding protein functions and designing peptides with desirable biological activities.
