Inquiry Basket
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
H-D-Arg(Pmc)-2-chlorotrityl resin is a specialized resin used primarily in peptide synthesis and related biochemical applications. Here are some key applications of H-D-Arg(Pmc)-2-chlorotrityl resin:
Solid-Phase Peptide Synthesis: H-D-Arg(Pmc)-2-chlorotrityl resin is extensively used in solid-phase peptide synthesis (SPPS) to assemble peptides efficiently. It provides a stable and linker-compatible platform, allowing for the sequential addition of amino acids. This resin supports the synthesis of peptides with high purity and minimal side reactions.
Bioconjugation: The resin is also employed in bioconjugation techniques, where peptides need to be linked to other biomolecules such as proteins or small molecules. The stable attachment provided by H-D-Arg(Pmc)-2-chlorotrityl resin ensures that the functional integrity of the peptide is maintained during the conjugation process. This is crucial for applications in drug delivery and diagnostic assays.
Antimicrobial Peptide Research: Researchers use H-D-Arg(Pmc)-2-chlorotrityl resin to synthesize antimicrobial peptides, which are key in studying and developing new antibiotics. The resin enables the incorporation of arginine residues that are essential for the activity of many antimicrobial peptides. This facilitates the creation of peptides that can combat multi-drug-resistant bacteria.
Proteomics: In proteomics, H-D-Arg(Pmc)-2-chlorotrityl resin is used for the synthesis of peptide libraries that help in the identification and characterization of protein interactions. By generating a diverse array of peptides, scientists can screen for binding partners and map protein interaction networks. This information is vital for understanding cellular processes and disease mechanisms.
