1.Synthesis and evaluation of Tc-99m-labeled RRL-containing peptide as a non-invasive tumor imaging agent in a mouse fibrosarcoma model.
Kim DW1,2, Kim WH2, Kim MH1, Kim CG3. Ann Nucl Med. 2015 Nov;29(9):779-85. doi: 10.1007/s12149-015-1002-6. Epub 2015 Jul 16.
OBJECTIVE: Arginine-arginine-leucine (RRL) is considered a tumor endothelial cell-specific binding sequence. RRL-containing peptide targeting tumor vessels is an excellent candidate for tumor imaging. In this study, we developed RRL-containing hexapeptides and evaluated their feasibility as a tumor imaging agent in a HT-1080 fibrosarcoma-bearing murine model.
2.A practical method for the quantitative assessment of non-enantioselective versus enantioselective interactions encountered in liquid chromatography on brush-type chiral stationary phase.
Levkin P1, Maier NM, Lindner W, Schurig V. J Chromatogr A. 2012 Dec 21;1269:270-8. doi: 10.1016/j.chroma.2012.10.006. Epub 2012 Oct 9.
A convenient experimental method for the quantitative assessment of enantioselective versus non-enantioselective interactions in liquid chromatography on brush-type chiral stationary phases (CSPs) is described. This procedure involves the systematic evaluation of the retention characteristics of resolved enantiomers as chiral selectands, SAs, on a set of CSPs containing chiral selectors, SOs, attached to an achiral support S with well-defined but different surface SO loading levels. The emerging body of retention data can be dissected into non-enantioselective and enantioselective increments by equations accounting separately for the two co-existing equilibrium processes, namely the "unproductive" adsorption of the enantiomers on the achiral domains of the CSP and their "productive" enantioselective association with the surface-anchored chiral SOs. The general applicability of this approach was demonstrated using a set of CSPs loaded with different densities of a quinine carbamate anion exchange-type SO, and three acidic model SAs, i.
3.Stability Test and Quantitative and Qualitative Analyses of the Amino Acids in Pharmacopuncture Extracted from Scolopendra subspinipes mutilans.
Cho G1, Han K1, Yoon J1. J Pharmacopuncture. 2015 Mar;18(1):44-55. doi: 10.3831/KPI.2015.18.005.
OBJECTIVES: Scolopendra subspinipes mutilans (S. subspinipes mutilans) is known as a traditional medicine and includes various amino acids, peptides and proteins. The amino acids in the pharmacopuncture extracted from S. subspinipes mutilans by using derivatization methods were analyzed quantitatively and qualitatively by using high performance liquid chromatography (HPLC) over a 12 month period to confirm its stability.