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Nα-Fmoc-Nδ-trityl-L-glutamine-2-chlorotrityl resin

Name: Nα-Fmoc-Nδ-trityl-L-glutamine-2-chlorotrityl resin
Brand: BOC Sciences
Rating: 5 (1 reviews)

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Pre-loaded resins for solid phase peptide and organic synthesis

Category

2-Chlorotrityl-Chloride-Resin with Amino Acids

Catalog number

BAT-000178

Synonyms

Fmoc-L-Gln(Trt)-2-chlorotrityl resin

DVB Crosslinking

1% DVB

Mesh Size

200-400 mesh

Substitution

0.3-0.9 meq/g

Storage

Store at 2-8°C

Nα-Fmoc-Nδ-trityl-L-glutamine-2-chlorotrityl resin, a specialized resin utilized in solid-phase peptide synthesis (SPPS), plays a pivotal role in crafting peptides with precise sequences.

Solid-Phase Peptide Synthesis: At the core of SPPS, this resin serves as a fundamental element in the creation of peptides with exact sequences and tailored modifications. By offering a sturdy platform for consecutive amino acid coupling, it guarantees the efficiency and purity of the synthesized peptides. The Fmoc and trityl groups play a crucial role in safeguarding functional groups during synthesis, allowing for meticulous control over deprotection and coupling reactions.

Custom Peptide Production: Researchers harness the power of Nα-Fmoc-Nδ-trityl-L-glutamine-2-chlorotrityl resin to craft bespoke peptides for diverse research endeavors and therapeutic interventions. This resin enables the generation of peptides containing specific functional residues, like L-glutamine, pivotal for protein-protein interactions and cellular signaling pathways.

Structural Biology: Within the realm of structural biology, this resin finds application in synthesizing peptides tailored for studies requiring precise modifications and utmost purity. By facilitating the creation of peptides suitable for NMR or crystallography analyses to unveil three-dimensional structures, it aids in deciphering peptide conformations crucial for understanding protein interactions and dynamics.

Biosensor Development: In the realm of biosensor technology, peptides synthesized on the Nα-Fmoc-Nδ-trityl-L-glutamine-2-chlorotrityl resin emerge as key components as recognition elements. These peptides can be finely tuned to bind with specific targets, such as biomolecules or pathogens, thereby heightening the sensitivity and specificity of biosensors. This application is pivotal in the development of cutting-edge diagnostic tools and real-time monitoring systems that find utility in healthcare and environmental surveillance.

1. Biological Properties and Therapeutic Applications of Propolis

José M Sforcin Phytother Res. 2016 Jun;30(6):894-905. doi: 10.1002/ptr.5605. Epub 2016 Mar 14.

Propolis is a resinous material collected by bees from bud and exudates of the plants, mixed with bee enzymes, pollen and wax. In this review, the biological properties of propolis and some therapeutic applications are discussed. The same biological activities have been investigated until today, using samples from different geographic regions. Thus, the study of the biological properties of a given sample should always be associated with its chemical composition and botanical source, representing a particular sample of a given geographic area, exploring its biological potential and the role of its constituents. Efforts have been carried out to explain propolis' mechanisms of action in vivo and in vitro, but the majority of propolis' targets and actions are still unclear. The number of formulations containing propolis and patents have increased, although propolis extracts have been used deliberately with different recommendations, not always mentioning the chemical composition, vegetal source and the methods of extraction. Clinical studies will help to obtain criterious recommendations in view of the expected outcomes. Further investigation should explore the effects of common compounds found in the samples from all over the world in an attempt to standardize the research on propolis and to obtain new drugs.

2. The 2-chlorotrityl resin: a worthy addition to the medicinal chemist's toolbox

W J Hoekstra Curr Med Chem. 2001 May;8(6):715-9. doi: 10.2174/0929867013373192.

The polystyrene-based 2-chlorotrityl resin was originally used in the synthesis of peptides using an Fmoc-amino acid/carboxyl-linked protocol. While traditionally employed to prepare a number of biologically active peptides, the resin has received increasing attention as a support for the synthesis of pseudopeptide and non-peptide molecules recently. This review focuses on 2-chlorotrityl resin-supported synthesis of small molecules that collectively display a broad range of biological activities.

3. Resin Glycosides from Convolvulaceae Family: An Update

Rani Maharani, Mohamad Fajar, Unang Supratman Molecules. 2022 Nov 23;27(23):8161. doi: 10.3390/molecules27238161.

Resin glycoside is a type of secondary metabolite isolated commonly from the Convolvulaceae family. It consists of oligosaccharides conjugated to organic acids with a larger percentage having a macrocyclic structure. The resin glycosides reported in this review is classified mostly based on the number of sugar units constructing the structure, which is correlated to the biological properties of the compounds. According to preliminary reviews, the protocols to isolate the compounds are not straightforward and require a special technique. Additionally, the structural determination of the isolated compounds needs to minimize the structure for the elucidation to become easier. Even though resin glycosides have a complicated structural skeleton, several total syntheses of the compounds have been reported in articles published from 2010 to date. This review is an update on the prior studies of the resin glycosides reported in 2010 and 2017. The review includes the classification, isolation techniques, structural determination, biological properties, and total synthesis of the resin glycosides.