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Fmoc-Thr(tBu)-Phe-Thr(tBu)-OH is a protected tripeptide used in peptide synthesis. The Fmoc (Fluorenylmethyloxycarbonyl) group protects the N-terminus of the threonine (Thr) residue, preventing it from reacting during synthesis. The hydroxyl groups on the side chains of both threonine residues are protected by tBu (tert-butyl) groups, ensuring these groups remain unreactive until selective deprotection is performed. Phe (Phenylalanine), the central amino acid, adds aromatic and hydrophobic characteristics to the peptide. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling. This compound is utilized to introduce threonine and phenylalanine into peptides, with specific protections to control the reactivity of the functional groups, ensuring efficient and selective peptide synthesis.
